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Pharmaceutical Activities of Saffron

We can use Saffron for pharmaceutical purposes. Here are some of the most important effects of saffron on human health.

There are clinical trials conducted evaluating the efficacy of pharmaceutical saffron in mild-to-moderate depression. The studies reported that saffron was more effective than placebo and at least equivalent to therapeutic doses of imipramine and fluoxetine. We can find No significant differences. In adverse effects in any of the studies. As a dietary supplement, saffron extracts may stop retinal damage in rats and have a role in the treatment of ischemic retinopathy, and age-related macular degeneration. Scientists reported Anti-nociceptive and anti-inflammatory activities from stigmas and petals of saffron. They reported Hypoxia at the vascular wall reduced. However, in another study 400 mg/day (for 7 days) of saffron showed no effect on the lipid profile of the healthy volunteers. In addition, we can see an anti-oxidant effect in human platelets together with the inhibition of lipid peroxidation. There is a report that reviewed the potential role of saffron extracts in cancer therapy. However, saffron appears to be a selective cytotoxic plant but scientist can not determine its mechanism clearly.

Scientists reported improvement of ethanol-impaired memory of mice, effects on learning behavior, neuronal cell death, and management of psoriasis from C. sativus. Saffron is generally not toxic when ingested in culinary amounts, but a lethal dose at 20 g and an abortifacient dose at 10 g can indicate in the literature. Adverse reactions such as rhino-conjunctivitis, bronchial asthma, cutaneous pruritus, and a case report of anaphylaxis have been reported.

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